8:30-9:00   Welcome participants

9:00-11:15   Session 2 – Host-Pathogen Interactions : Effectors diversity and function

| Chair: Abdelrahim Zoued 

9:00   Keynote lecture – Suzana SALCEDO
“The Ins and Outs of Brucella: deciphering the role of effectors in pathogenesis”

9:45   Monica ROLANDO
“Characterization of a new nucleomodulin of Legionella pneumophila”

10:05  Matteo BONAZZI
“The multifunction Coxiella effector Vice stimulates macropinocytosis and interferes with the ESCRT machinery”

10:25  Gunnar SCHROEDER 
“Disruption of the nucleoli and translation by a Legionella Dot/Icm T4SS effector”

10:45  Main Talk – Steffen BACKERT
“Composition and function of the Helicobacter pylori cag pathogenicity island encoded type IV secretion system”

11:15-12:30   Coffee Break & Poster Session 1

12:30-14:00   Lunch

14:00-16:30   City Tour

16:30-18:45   Session 3 – T4SS Structure and Function : Conjugative systems – DNA import/export systems

| Chair: Kevin Macé

16:30   Keynote lecture – Peter CHRISTIE
“Structural and Functional Plasticity of the T4SSs Exemplified Through Studies of the F system”

17:15   Shubha UDUPA
“Visualizing the structure and dynamics of the horizontal gene transfer during bacterial conjugation“

17:35  Haifa LAROUSSI
“Exploration of DNA processing mediated by MOBT relaxases during bacterial conjugation”

17:55  Sunada WILLIAMS 
“Cryo-EM structure of the F plasmid relaxosome provides a molecular basis for DNA recruitment and processing in bacterial conjugation”

18:15  Main Talk – Aravindan ILANGOVAN
“Molecular Mechanism For Loading Two Relaxases During Conjugation Initiation”

20:00  Diner at the Exclesior (optional)

8:15-8:45   Welcome participants

8:45-11:00 Session 4 – Bioinformatics, Genomics and Evolution : Detection and classification, Diversity and Evolution, Bioinformatic Tools

| Chair: Virginie Libante

8:45  Keynote lecture – Hélène CHIAPELLO and Nathalie LEBLOND-BOURGET

“Unveilling Integrative Conjugative Elements: detection and annotation in Bacillota genomes”

9:30  Toufik HAMADOUCHE
“PO-CBR for delimiting integrated mobile elements transferred by conjugation“

9:50  Sophie PAYOT
“Prevalence and diversity of Integrative and conjugative or mobilizable elements carrying antimicrobial resistance genes in Streptococcus suis“

10:10  Daniel GARCIA-LOPEZ
“Conjugative sabotage: new fertility inhibitors against broad-host-range plasmids“

10:30  Main talk – Charles COLUZZI
“Evolution of plasmid mobility: origin and fate of non-conjugative plasmids“

11:00-11:20 Coffee Break

11:20-12:30 Session 5 – T4SS Structure and Function : Non-Canonical Systems, Interbacterial Systems

 | Chair: Ronnie Bertsson

11:20  Main talk – Chuck FARAH
“Substrate selection and fratricide avoidance by the bactericidal Type IV secretion system of Xanthomonadaceae“

11:50  Chloé PEDUZZI
“Type IV secretion system drives interbacterial competition in the plant pathogen Xanthomonas“

12:10  Pauline GASCHT
“The non-canonical TraB-dependent Actinomycete ICEs (AICEs) mediate large-scale chromosomal transfer in Streptomyces“

12:30-14:00 Lunch

14:00-17:20 Session 6 – Host-Pathogen Interactions : Targeting eucaryotic signaling pathways

| Chair: Steffen Backert

14:00  Keynote lecture – Sagar BHOGARAJU
“Effectors of Legionella pneumophila and their interaction with the host ubiquitin system“

14:45  Maren KETTERER
“Revisiting effector functions: involvement of a putative T4SS effector in the envelope integrity of Brucella“

15:05  Christine JOSENHANS
“Exploring novel protein-protein interactions and functions of selected Helicobacter pylori Cag Type 4 secretion system (CagT4SS) outer proteins“

15:25-16:30 Coffee Break & Poster Session 2

16:30  Main talk – Christoph DEHIO
“Translocation of YopJ family effector proteins through the VirB/VirD4 T4SS of Bartonella“

17:00  Carmen BUCHRIESER
“Legionella pneumophila: Assessment of effector secretion kinetics in real time in Acanthamoeba“

20:00  Diner Gala at the Grands Salons

8:15-8:45  Welcome partcipants

8:45-10:15 Session 7 – T4SS Structure and Function : T4SS effectors recruitment

| Chair: Christine Josenhans

8:45   Main Talk – Samuel WAGNER
“The T4bSS of Legionella features a two-step secretion pathway with an inner membrane intermediate for secretion of transmembrane effectors“

9:15   Chloé DUGELAY
“Exploring the structure and function of Brucella abortus virulence factor VirJ in T4SS effectors translocation“

9:35   Main talk – Carrie SHAFFER
“Architectural asymmetry enables DNA transport through the Helicobacter pylori cag Type IV secretion system“

10:05-10:25  Coffee Break

10:25-13:00 Session 8 – Impact of Conjugative Transfer : Dissemination in the environment, Consequence on bacterial fitness, Mobilization

| Chair: Xavier Bellanger

10:25   Keynote lecture – Uli KLÜMPER
“Insights into the T4SS-mediated spread of plasmids and antimicrobial resistance“

11:10   Matxalen LLOSA
“Bacterial conjugation – based tools for manipulating and exploring long-range horizontal gene transfer“

11:30  Laurent TERRADOT
“Structural insights into a ParB-like protein of the F-plasmid that reprograms the gene expression profile of the recipient cell“

11:50  Sarah BIGOT
“Competition between conjugative plasmids by fertility inhibition protein“

12:10  Virginie LIBANTE
“Uncovering the role of IMEs in antimicrobial resistance and horizontal gene transfer“

12:30   Main Talk – Vincent BURRUS
“Entry and surface exclusion of IncC plasmids and SGI1: an asymmetric interplay gene transfer“

13:00  Poster & Talk Prices

    Concluding remarks

    Lunch bag (optionnal)